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| Unknown | 1992-06-18 | 270.8 KB |
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| Confidence | Program | Detection | Match Type | Support
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|---|
| 66%
| dexvert
| OS/2 Installation Package (archive/os2InstallPackage)
| ext
| Supported |
| 1%
| dexvert
| BeOS Installation Package (archive/beOSInstallPackage)
| ext
| Unsupported |
| 1%
| dexvert
| Newton Package (archive/newtonPackage)
| ext
| Unsupported |
| 1%
| dexvert
| Independence War 2 mod Package (other/independenceWar2ModPackage)
| ext
| Unsupported |
| 100%
| file
| data
| default
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hex view+--------+-------------------------+-------------------------+--------+--------+
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|00000580| 00 00 00 00 00 00 05 3b | 04 00 00 00 00 00 24 55 |.......;|......$U|
|00000590| 6e 69 71 75 65 5f 49 44 | 7b 59 52 45 30 30 30 30 |nique_ID|{YRE0000|
|000005a0| 31 7d 0d 0a 24 54 69 74 | 6c 65 7b 50 72 65 76 61 |1}..$Tit|le{Preva|
|000005b0| 6c 65 6e 63 65 20 6f 66 | 20 50 6f 6c 79 63 79 73 |lence of| Polycys|
|000005c0| 74 69 63 20 4f 76 61 72 | 69 65 73 20 69 6e 20 57 |tic Ovar|ies in W|
|000005d0| 6f 6d 65 6e 20 57 69 74 | 68 20 41 63 6e 65 7d 0d |omen Wit|h Acne}.|
|000005e0| 0a 24 41 75 74 68 6f 72 | 7b 0d 0a 50 65 73 65 72 |.$Author|{..Peser|
|000005f0| 69 63 6f 2c 20 41 0d 0a | 41 6e 67 65 6c 6f 6e 69 |ico, A..|Angeloni|
|00000600| 2c 20 47 0d 0a 42 65 72 | 74 6f 6c 69 2c 20 50 0d |, G..Ber|toli, P.|
|00000610| 0a 4d 61 72 69 6e 69 2c | 20 41 0d 0a 50 69 76 61 |.Marini,| A..Piva|
|00000620| 2c 20 47 0d 0a 50 61 6e | 63 69 65 72 61 2c 20 41 |, G..Pan|ciera, A|
|00000630| 0d 0a 53 75 6d 61 2c 20 | 56 7d 0d 0a 24 41 66 66 |..Suma, |V}..$Aff|
|00000640| 69 6c 69 61 74 69 6f 6e | 7b 55 6e 69 76 20 64 69 |iliation|{Univ di|
|00000650| 20 50 61 64 6f 76 61 3b | 20 4f 73 70 65 64 61 6c | Padova;| Ospedal|
|00000660| 65 20 43 69 76 69 6c 65 | 20 64 69 20 50 61 64 6f |e Civile| di Pado|
|00000670| 76 61 2c 20 50 61 64 6f | 76 61 2c 20 49 74 61 6c |va, Pado|va, Ital|
|00000680| 79 7d 0d 0a 24 4a 6f 75 | 72 6e 61 6c 7b 41 72 63 |y}..$Jou|rnal{Arc|
|00000690| 68 20 44 65 72 6d 61 74 | 6f 6c 20 52 65 73 7d 0d |h Dermat|ol Res}.|
|000006a0| 0a 24 56 6f 6c 75 6d 65 | 7b 32 38 31 7d 0d 0a 24 |.$Volume|{281}..$|
|000006b0| 50 61 67 65 7b 35 30 32 | 2d 35 30 33 7d 0d 0a 24 |Page{502|-503}..$|
|000006c0| 44 61 74 65 7b 31 39 38 | 39 7d 0d 0a 24 59 42 56 |Date{198|9}..$YBV|
|000006d0| 6f 6c 7b 31 39 39 31 20 | 59 65 61 72 20 42 6f 6f |ol{1991 |Year Boo|
|000006e0| 6b 20 6f 66 20 44 65 72 | 6d 61 74 6f 6c 6f 67 79 |k of Der|matology|
|000006f0| 7d 0d 0a 24 43 68 61 70 | 74 65 72 7b 31 2d 31 7d |}..$Chap|ter{1-1}|
|00000700| 0d 0a 24 59 42 45 64 69 | 74 6f 72 7b 44 72 73 2e |..$YBEdi|tor{Drs.|
|00000710| 20 53 6f 62 65 72 20 61 | 6e 64 20 46 69 74 7a 70 | Sober a|nd Fitzp|
|00000720| 61 74 72 69 63 6b 7d 0d | 0a 24 54 61 62 6c 65 7b |atrick}.|.$Table{|
|00000730| 7d 0d 0a 24 43 6f 6d 6d | 65 6e 74 61 74 6f 72 7b |}..$Comm|entator{|
|00000740| 4a 2e 43 2e 20 41 6c 70 | 65 72 2c 20 4d 2e 44 2e |J.C. Alp|er, M.D.|
|00000750| 7d 0d 0a 0d 0a 43 6f 70 | 79 72 69 67 68 74 20 28 |}....Cop|yright (|
|00000760| 43 29 20 59 65 61 72 20 | 42 6f 6f 6b 20 4d 65 64 |C) Year |Book Med|
|00000770| 69 63 61 6c 20 50 75 62 | 6c 69 73 68 65 72 73 2c |ical Pub|lishers,|
|00000780| 20 49 6e 63 2e 20 20 31 | 39 39 31 0d 0a 0d 0a 31 | Inc. 1|991....1|
|00000790| 39 39 31 20 59 65 61 72 | 20 42 6f 6f 6b 20 6f 66 |991 Year| Book of|
|000007a0| 20 44 65 72 6d 61 74 6f | 6c 6f 67 79 0d 0a 0d 0a | Dermato|logy....|
|000007b0| 43 68 61 70 74 65 72 20 | 31 2d 2d 41 63 6e 65 20 |Chapter |1--Acne |
|000007c0| 61 6e 64 20 52 65 6c 61 | 74 65 64 20 44 69 73 6f |and Rela|ted Diso|
|000007d0| 72 64 65 72 73 0d 0a 0d | 0a 2d 2d 2d 2d 2d 2d 2d |rders...|.-------|
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|00000820| 2d 2d 2d 2d 2d 2d 2d 0d | 0a 50 72 65 76 61 6c 65 |-------.|.Prevale|
|00000830| 6e 63 65 20 6f 66 20 50 | 6f 6c 79 63 79 73 74 69 |nce of P|olycysti|
|00000840| 63 20 4f 76 61 72 69 65 | 73 20 69 6e 20 57 6f 6d |c Ovarie|s in Wom|
|00000850| 65 6e 20 57 69 74 68 20 | 41 63 6e 65 0d 0a 0d 0a |en With |Acne....|
|00000860| 50 65 73 65 72 69 63 6f | 20 41 3b 20 41 6e 67 65 |Peserico| A; Ange|
|00000870| 6c 6f 6e 69 20 47 3b 20 | 42 65 72 74 6f 6c 69 20 |loni G; |Bertoli |
|00000880| 50 3b 20 4d 61 72 69 6e | 69 20 41 3b 20 50 69 76 |P; Marin|i A; Piv|
|00000890| 61 20 47 3b 20 50 61 6e | 63 69 65 72 61 20 41 3b |a G; Pan|ciera A;|
|000008a0| 20 53 75 6d 61 20 56 0d | 0a 28 55 6e 69 76 20 64 | Suma V.|.(Univ d|
|000008b0| 69 20 50 61 64 6f 76 61 | 3b 20 4f 73 70 65 64 61 |i Padova|; Ospeda|
|000008c0| 6c 65 20 43 69 76 69 6c | 65 20 64 69 20 50 61 64 |le Civil|e di Pad|
|000008d0| 6f 76 61 2c 20 50 61 64 | 6f 76 61 2c 20 49 74 61 |ova, Pad|ova, Ita|
|000008e0| 6c 79 29 0d 0a 41 72 63 | 68 20 44 65 72 6d 61 74 |ly)..Arc|h Dermat|
|000008f0| 6f 6c 20 52 65 73 20 32 | 38 31 3a 35 30 32 2d 35 |ol Res 2|81:502-5|
|00000900| 30 33 2c 20 31 39 38 39 | 0d 0a 2d 2d 2d 2d 2d 2d |03, 1989|..------|
|00000910| 2d 2d 2d 2d 2d 2d 2d 2d | 2d 2d 2d 2d 2d 2d 2d 2d |--------|--------|
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|00000930| 2d 2d 2d 2d 2d 2d 2d 2d | 2d 2d 2d 2d 2d 2d 2d 2d |--------|--------|
|00000940| 2d 2d 2d 2d 2d 2d 2d 2d | 2d 2d 2d 2d 2d 2d 2d 2d |--------|--------|
|00000950| 2d 2d 2d 2d 2d 2d 2d 2d | 0d 0a 0d 0a 43 6f 70 79 |--------|....Copy|
|00000960| 72 69 67 68 74 20 28 43 | 29 20 59 65 61 72 20 42 |right (C|) Year B|
|00000970| 6f 6f 6b 20 4d 65 64 69 | 63 61 6c 20 50 75 62 6c |ook Medi|cal Publ|
|00000980| 69 73 68 65 72 73 2c 20 | 49 6e 63 2e 20 20 31 39 |ishers, |Inc. 19|
|00000990| 39 31 0d 0a 0d 0a 31 39 | 39 31 20 59 65 61 72 20 |91....19|91 Year |
|000009a0| 42 6f 6f 6b 20 6f 66 20 | 44 65 72 6d 61 74 6f 6c |Book of |Dermatol|
|000009b0| 6f 67 79 0d 0a 0d 0a 41 | 62 73 74 72 61 63 74 0d |ogy....A|bstract.|
|000009c0| 0a 0d 0a 20 20 20 20 20 | 54 68 65 20 70 72 65 76 |... |The prev|
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|000009f0| 20 73 74 75 64 69 65 64 | 20 69 6e 20 77 6f 6d 65 | studied| in wome|
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|00000a10| 0a 77 69 74 68 20 6e 6f | 20 6d 65 6e 73 74 72 75 |.with no| menstru|
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|00000a80| 20 61 67 65 64 20 31 34 | 2d 34 35 20 79 65 61 72 | aged 14|-45 year|
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|00000b20| 20 20 20 20 20 50 6f 6c | 79 63 79 73 74 69 63 20 | Pol|ycystic |
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|00000d40| 54 68 65 73 65 20 61 70 | 70 61 72 65 6e 74 6c 79 |These ap|parently|
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|00001cf0| 2d 2d 2d 0d 0a 0d 0a 41 | 62 73 74 72 61 63 74 0d |---....A|bstract.|
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|00001f70| 72 69 61 6e 20 61 62 6e | 6f 72 6d 61 6c 69 74 79 |rian abn|ormality|
|00001f80| 2e 0d 0a 44 69 68 79 64 | 72 6f 78 79 74 65 73 74 |...Dihyd|roxytest|
|00001f90| 6f 73 74 65 72 6f 6e 65 | 20 6c 65 76 65 6c 73 20 |osterone| levels |
|00001fa0| 77 65 72 65 20 69 6e 63 | 72 65 61 73 65 64 20 69 |were inc|reased i|
|00001fb0| 6e 20 37 20 77 6f 6d 65 | 6e 20 77 69 74 68 20 61 |n 7 wome|n with a|
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|00002000| 20 70 65 72 69 6f 72 61 | 6c 20 61 63 6e 65 20 68 | periora|l acne h|
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|00002020| 20 68 69 67 68 20 64 65 | 68 79 64 72 6f 65 70 69 | high de|hydroepi|
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|00002040| 66 61 74 65 20 6c 65 76 | 65 6c 73 2e 0d 0a 20 20 |fate lev|els... |
|00002050| 20 20 20 54 68 65 20 70 | 72 65 73 65 6e 63 65 20 | The p|resence |
|00002060| 6f 66 20 70 6f 6c 79 63 | 79 73 74 69 63 20 6f 76 |of polyc|ystic ov|
|00002070| 61 72 69 65 73 20 6d 61 | 79 20 64 69 73 74 69 6e |aries ma|y distin|
|00002080| 67 75 69 73 68 20 61 20 | 73 75 62 67 72 6f 75 70 |guish a |subgroup|
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|000020a0| 74 68 20 61 63 6e 65 20 | 69 6e 20 77 68 6f 6d 20 |th acne |in whom |
|000020b0| 68 6f 72 6d 6f 6e 61 6c | 20 73 74 75 64 69 65 73 |hormonal| studies|
|000020c0| 20 61 72 65 20 69 6e 64 | 69 63 61 74 65 64 2e 20 | are ind|icated. |
|000020d0| 20 41 74 74 65 6e 74 69 | 6f 6e 20 74 6f 20 74 68 | Attenti|on to th|
|000020e0| 65 20 75 6e 64 65 72 6c | 79 69 6e 67 0d 0a 64 69 |e underl|ying..di|
|000020f0| 73 6f 72 64 65 72 20 6d | 61 79 20 77 65 6c 6c 20 |sorder m|ay well |
|00002100| 69 6d 70 72 6f 76 65 20 | 74 68 65 20 6d 61 6e 61 |improve |the mana|
|00002110| 67 65 6d 65 6e 74 20 6f | 66 20 61 63 6e 65 20 69 |gement o|f acne i|
|00002120| 6e 20 74 68 65 73 65 20 | 70 61 74 69 65 6e 74 73 |n these |patients|
|00002130| 2e 0d 0a 0d 0a 50 6f 73 | 74 2d 43 6f 6d 6d 65 6e |.....Pos|t-Commen|
|00002140| 74 0d 0a 0d 0a 20 20 20 | 20 20 54 68 65 20 72 65 |t.... | The re|
|00002150| 73 75 6c 74 73 20 6f 66 | 20 74 68 69 73 20 73 74 |sults of| this st|
|00002160| 75 64 79 20 61 72 65 20 | 70 6f 74 65 6e 74 69 61 |udy are |potentia|
|00002170| 6c 6c 79 20 69 6d 70 6f | 72 74 61 6e 74 20 62 75 |lly impo|rtant bu|
|00002180| 74 20 6e 65 65 64 20 74 | 6f 20 62 65 0d 0a 63 6f |t need t|o be..co|
|00002190| 6e 66 69 72 6d 65 64 2e | 20 20 54 68 65 20 62 69 |nfirmed.| The bi|
|000021a0| 67 67 65 73 74 20 70 72 | 6f 62 6c 65 6d 20 77 69 |ggest pr|oblem wi|
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|000021c0| 20 74 68 69 73 20 72 65 | 70 6f 72 74 20 69 73 20 | this re|port is |
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|000021f0| 74 68 65 20 73 74 75 64 | 79 20 61 6e 64 20 63 6f |the stud|y and co|
|00002200| 6e 74 72 6f 6c 20 67 72 | 6f 75 70 73 20 61 72 65 |ntrol gr|oups are|
|00002210| 20 67 61 74 68 65 72 65 | 64 2e 20 20 49 74 20 69 | gathere|d. It i|
|00002220| 73 0d 0a 69 6d 70 6f 72 | 74 61 6e 74 20 74 6f 20 |s..impor|tant to |
|00002230| 6b 6e 6f 77 20 69 66 20 | 62 6f 74 68 20 6f 72 20 |know if |both or |
|00002240| 65 69 74 68 65 72 20 77 | 65 72 65 20 64 65 72 69 |either w|ere deri|
|00002250| 76 65 64 20 66 72 6f 6d | 20 61 6e 20 65 6e 64 6f |ved from| an endo|
|00002260| 63 72 69 6e 65 20 6f 72 | 0d 0a 64 65 72 6d 61 74 |crine or|..dermat|
|00002270| 6f 6c 6f 67 79 20 63 6c | 69 6e 69 63 2e 20 20 49 |ology cl|inic. I|
|00002280| 6e 20 74 68 65 20 6d 65 | 61 6e 74 69 6d 65 2c 20 |n the me|antime, |
|00002290| 69 74 20 6d 69 67 68 74 | 20 62 65 20 70 72 75 64 |it might| be prud|
|000022a0| 65 6e 74 20 74 6f 20 64 | 6f 20 73 6f 6d 65 20 73 |ent to d|o some s|
|000022b0| 63 72 65 65 6e 69 6e 67 | 0d 0a 6f 66 20 77 6f 6d |creening|..of wom|
|000022c0| 65 6e 20 77 69 74 68 20 | 6c 61 74 65 20 6f 6e 73 |en with |late ons|
|000022d0| 65 74 20 6f 72 20 70 65 | 72 73 69 73 74 65 6e 74 |et or pe|rsistent|
|000022e0| 20 61 63 6e 65 2e 20 20 | 53 65 65 20 61 6c 73 6f | acne. |See also|
|000022f0| 20 74 68 65 20 73 74 75 | 64 79 20 62 79 20 50 65 | the stu|dy by Pe|
|00002300| 73 65 72 69 63 6f 2c 0d | 0a 65 74 20 61 6c 20 28 |serico,.|.et al (|
|00002310| 41 62 73 74 72 61 63 74 | 20 31 2d 31 29 2e 2d 2d |Abstract| 1-1).--|
|00002320| 4a 2e 43 2e 20 41 6c 70 | 65 72 2c 20 4d 2e 44 2e |J.C. Alp|er, M.D.|
|00002330| 0d 0a 24 55 6e 69 71 75 | 65 5f 49 44 7b 59 52 45 |..$Uniqu|e_ID{YRE|
|00002340| 30 30 30 30 34 7d 0d 0a | 24 54 69 74 6c 65 7b 53 |00004}..|$Title{S|
|00002350| 74 65 72 6f 69 64 20 41 | 63 6e 65 7d 0d 0a 24 41 |teroid A|cne}..$A|
|00002360| 75 74 68 6f 72 7b 0d 0a | 48 75 72 77 69 74 7a 2c |uthor{..|Hurwitz,|
|00002370| 20 52 4d 7d 0d 0a 24 41 | 66 66 69 6c 69 61 74 69 | RM}..$A|ffiliati|
|00002380| 6f 6e 7b 53 74 20 56 69 | 6e 63 65 6e 74 20 48 6f |on{St Vi|ncent Ho|
|00002390| 73 70 20 61 6e 64 20 48 | 65 61 6c 74 68 20 43 61 |sp and H|ealth Ca|
|000023a0| 72 65 20 43 74 72 2c 20 | 49 6e 64 69 61 6e 61 70 |re Ctr, |Indianap|
|000023b0| 6f 6c 69 73 7d 0d 0a 24 | 4a 6f 75 72 6e 61 6c 7b |olis}..$|Journal{|
|000023c0| 4a 20 41 6d 20 41 63 61 | 64 20 44 65 72 6d 61 74 |J Am Aca|d Dermat|
|000023d0| 6f 6c 7d 0d 0a 24 56 6f | 6c 75 6d 65 7b 32 31 7d |ol}..$Vo|lume{21}|
|000023e0| 0d 0a 24 50 61 67 65 7b | 31 31 37 39 2d 31 31 38 |..$Page{|1179-118|
|000023f0| 31 7d 0d 0a 24 44 61 74 | 65 7b 31 39 38 39 7d 0d |1}..$Dat|e{1989}.|
|00002400| 0a 24 59 42 56 6f 6c 7b | 31 39 39 31 20 59 65 61 |.$YBVol{|1991 Yea|
|00002410| 72 20 42 6f 6f 6b 20 6f | 66 20 44 65 72 6d 61 74 |r Book o|f Dermat|
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|00002430| 7b 31 2d 34 7d 0d 0a 24 | 59 42 45 64 69 74 6f 72 |{1-4}..$|YBEditor|
|00002440| 7b 44 72 73 2e 20 53 6f | 62 65 72 20 61 6e 64 20 |{Drs. So|ber and |
|00002450| 46 69 74 7a 70 61 74 72 | 69 63 6b 7d 0d 0a 24 54 |Fitzpatr|ick}..$T|
|00002460| 61 62 6c 65 7b 7d 0d 0a | 24 43 6f 6d 6d 65 6e 74 |able{}..|$Comment|
|00002470| 61 74 6f 72 7b 7d 0d 0a | 0d 0a 43 6f 70 79 72 69 |ator{}..|..Copyri|
|00002480| 67 68 74 20 28 43 29 20 | 59 65 61 72 20 42 6f 6f |ght (C) |Year Boo|
|00002490| 6b 20 4d 65 64 69 63 61 | 6c 20 50 75 62 6c 69 73 |k Medica|l Publis|
|000024a0| 68 65 72 73 2c 20 49 6e | 63 2e 20 20 31 39 39 31 |hers, In|c. 1991|
|000024b0| 0d 0a 0d 0a 31 39 39 31 | 20 59 65 61 72 20 42 6f |....1991| Year Bo|
|000024c0| 6f 6b 20 6f 66 20 44 65 | 72 6d 61 74 6f 6c 6f 67 |ok of De|rmatolog|
|000024d0| 79 0d 0a 0d 0a 43 68 61 | 70 74 65 72 20 31 2d 2d |y....Cha|pter 1--|
|000024e0| 41 63 6e 65 20 61 6e 64 | 20 52 65 6c 61 74 65 64 |Acne and| Related|
|000024f0| 20 53 75 62 6a 65 63 74 | 73 0d 0a 0d 0a 2d 2d 2d | Subject|s....---|
|00002500| 2d 2d 2d 2d 2d 2d 2d 2d | 2d 2d 2d 2d 2d 2d 2d 2d |--------|--------|
|00002510| 2d 2d 2d 2d 2d 2d 2d 2d | 2d 2d 2d 2d 2d 2d 2d 2d |--------|--------|
|00002520| 2d 2d 2d 2d 2d 2d 2d 2d | 2d 2d 2d 2d 2d 2d 2d 2d |--------|--------|
|00002530| 2d 2d 2d 2d 2d 2d 2d 2d | 2d 2d 2d 2d 2d 2d 2d 2d |--------|--------|
|00002540| 2d 2d 2d 2d 2d 2d 2d 2d | 2d 2d 2d 0d 0a 53 74 65 |--------|---..Ste|
|00002550| 72 6f 69 64 20 41 63 6e | 65 0d 0a 0d 0a 48 75 72 |roid Acn|e....Hur|
|00002560| 77 69 74 7a 20 52 4d 0d | 0a 28 53 74 20 56 69 6e |witz RM.|.(St Vin|
|00002570| 63 65 6e 74 20 48 6f 73 | 70 20 61 6e 64 20 48 65 |cent Hos|p and He|
|00002580| 61 6c 74 68 20 43 61 72 | 65 20 43 74 72 2c 20 49 |alth Car|e Ctr, I|
|00002590| 6e 64 69 61 6e 61 70 6f | 6c 69 73 29 0d 0a 4a 20 |ndianapo|lis)..J |
|000025a0| 41 6d 20 41 63 61 64 20 | 44 65 72 6d 61 74 6f 6c |Am Acad |Dermatol|
|000025b0| 20 32 31 3a 31 31 37 39 | 2d 31 31 38 31 2c 20 31 | 21:1179|-1181, 1|
|000025c0| 39 38 39 0d 0a 2d 2d 2d | 2d 2d 2d 2d 2d 2d 2d 2d |989..---|--------|
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|000025f0| 2d 2d 2d 2d 2d 2d 2d 2d | 2d 2d 2d 2d 2d 2d 2d 2d |--------|--------|
|00002600| 2d 2d 2d 2d 2d 2d 2d 2d | 2d 2d 2d 2d 2d 2d 2d 2d |--------|--------|
|00002610| 2d 2d 2d 0d 0a 0d 0a 41 | 62 73 74 72 61 63 74 0d |---....A|bstract.|
|00002620| 0a 0d 0a 20 20 20 20 20 | 53 74 65 72 6f 69 64 20 |... |Steroid |
|00002630| 61 63 6e 65 20 68 61 73 | 20 62 65 63 6f 6d 65 20 |acne has| become |
|00002640| 6d 6f 72 65 20 63 6f 6d | 6d 6f 6e 20 73 69 6e 63 |more com|mon sinc|
|00002650| 65 20 74 68 65 20 75 73 | 65 20 6f 66 20 63 6f 72 |e the us|e of cor|
|00002660| 74 69 63 6f 73 74 65 72 | 6f 69 64 73 20 69 6e 0d |ticoster|oids in.|
|00002670| 0a 6f 72 67 61 6e 20 74 | 72 61 6e 73 70 6c 61 6e |.organ t|ransplan|
|00002680| 74 20 73 75 72 67 65 72 | 79 20 61 6e 64 20 6f 6e |t surger|y and on|
|00002690| 63 6f 6c 6f 67 69 63 20 | 74 72 65 61 74 6d 65 6e |cologic |treatmen|
|000026a0| 74 20 72 65 67 69 6d 65 | 6e 73 2e 20 20 54 6f 20 |t regime|ns. To |
|000026b0| 63 6c 61 72 69 66 79 20 | 74 68 65 0d 0a 70 61 74 |clarify |the..pat|
|000026c0| 68 6f 67 65 6e 65 73 69 | 73 20 6f 66 20 74 68 69 |hogenesi|s of thi|
|000026d0| 73 20 63 6f 6e 64 69 74 | 69 6f 6e 2c 20 31 35 20 |s condit|ion, 15 |
|000026e0| 73 6b 69 6e 20 62 69 6f | 70 73 79 20 73 70 65 63 |skin bio|psy spec|
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|00002710| 6f 69 64 20 61 63 6e 65 | 20 77 65 72 65 20 73 74 |oid acne| were st|
|00002720| 75 64 69 65 64 2e 0d 0a | 20 20 20 20 20 53 65 72 |udied...| Ser|
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|000027a0| 73 20 28 65 61 72 6c 79 | 20 6d 69 63 72 6f 63 6f |s (early| microco|
|000027b0| 6d 65 64 6f 20 66 6f 72 | 6d 61 74 69 6f 6e 29 2c |medo for|mation),|
|000027c0| 0d 0a 61 6e 64 20 69 6e | 66 75 6e 64 69 62 75 6c |..and in|fundibul|
|000027d0| 61 72 20 77 61 6c 6c 20 | 74 68 69 6e 6e 69 6e 67 |ar wall |thinning|
|000027e0| 20 69 6e 20 73 6f 6d 65 | 20 70 61 70 75 6c 65 73 | in some| papules|
|000027f0| 2c 20 62 75 74 20 69 6e | 20 6d 6f 73 74 20 70 61 |, but in| most pa|
|00002800| 70 75 6c 65 73 20 73 68 | 6f 77 65 64 0d 0a 69 6e |pules sh|owed..in|
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|000035f0| 6f 20 70 75 62 6c 69 63 | 61 74 69 6f 6e 2e 0d 0a |o public|ation...|
|00003600| 41 6c 74 68 6f 75 67 68 | 20 74 68 65 20 61 75 74 |Although| the aut|
|00003610| 68 6f 72 73 20 61 72 67 | 75 65 20 74 68 61 74 20 |hors arg|ue that |
|00003620| 74 68 69 73 20 6d 65 74 | 68 6f 64 6f 6c 6f 67 79 |this met|hodology|
|00003630| 20 63 6f 75 6c 64 20 62 | 65 20 75 73 65 64 20 66 | could b|e used f|
|00003640| 6f 72 0d 0a 70 6f 73 74 | 6d 61 72 6b 65 74 69 6e |or..post|marketin|
|00003650| 67 20 73 75 72 76 65 69 | 6c 6c 61 6e 63 65 2c 20 |g survei|llance, |
|00003660| 69 66 20 75 73 65 66 75 | 6c 20 69 6e 66 6f 72 6d |if usefu|l inform|
|00003670| 61 74 69 6f 6e 20 69 73 | 20 74 6f 20 62 65 20 6f |ation is| to be o|
|00003680| 62 74 61 69 6e 65 64 2c | 20 68 69 67 68 65 72 0d |btained,| higher.|
|00003690| 0a 65 6e 72 6f 6c 6c 6d | 65 6e 74 20 72 61 74 65 |.enrollm|ent rate|
|000036a0| 73 20 61 6e 64 20 61 20 | 6d 75 63 68 20 68 69 67 |s and a |much hig|
|000036b0| 68 65 72 20 66 6f 6c 6c | 6f 77 2d 75 70 20 72 61 |her foll|ow-up ra|
|000036c0| 74 65 20 77 6f 75 6c 64 | 20 73 65 65 6d 20 64 65 |te would| seem de|
|000036d0| 73 69 72 61 62 6c 65 2e | 20 20 41 0d 0a 66 75 72 |sirable.| A..fur|
|000036e0| 74 68 65 72 20 64 69 66 | 66 69 63 75 6c 74 79 20 |ther dif|ficulty |
|000036f0| 69 73 20 74 68 65 20 6c | 61 63 6b 20 6f 66 20 63 |is the l|ack of c|
|00003700| 6f 6d 70 61 72 61 74 69 | 76 65 20 69 6e 63 69 64 |omparati|ve incid|
|00003710| 65 6e 63 65 20 64 61 74 | 61 20 73 6f 20 74 68 61 |ence dat|a so tha|
|00003720| 74 20 6f 6e 65 20 63 61 | 6e 0d 0a 64 65 74 65 72 |t one ca|n..deter|
|00003730| 6d 69 6e 65 20 77 68 61 | 74 20 69 6e 20 66 61 63 |mine wha|t in fac|
|00003740| 74 20 77 6f 75 6c 64 20 | 62 65 20 74 68 65 20 65 |t would |be the e|
|00003750| 78 70 65 63 74 65 64 20 | 72 61 74 65 73 20 6f 66 |xpected |rates of|
|00003760| 20 61 64 76 65 72 73 65 | 20 65 76 65 6e 74 73 20 | adverse| events |
|00003770| 73 75 63 68 20 61 73 0d | 0a 64 69 61 72 72 68 65 |such as.|.diarrhe|
|00003780| 61 20 69 6e 20 74 68 69 | 73 20 70 6f 70 75 6c 61 |a in thi|s popula|
|00003790| 74 69 6f 6e 2e 2d 2d 52 | 2e 53 2e 20 20 53 74 65 |tion.--R|.S. Ste|
|000037a0| 72 6e 2c 20 4d 2e 44 2e | 0d 0a 24 55 6e 69 71 75 |rn, M.D.|..$Uniqu|
|000037b0| 65 5f 49 44 7b 59 52 45 | 30 30 30 30 36 7d 0d 0a |e_ID{YRE|00006}..|
|000037c0| 24 54 69 74 6c 65 7b 53 | 74 72 61 74 65 67 79 20 |$Title{S|trategy |
|000037d0| 6f 66 20 41 63 6e 65 20 | 54 68 65 72 61 70 79 20 |of Acne |Therapy |
|000037e0| 57 69 74 68 20 4c 6f 6e | 67 2d 54 65 72 6d 20 41 |With Lon|g-Term A|
|000037f0| 6e 74 69 62 69 6f 74 69 | 63 73 7d 0d 0a 24 41 75 |ntibioti|cs}..$Au|
|00003800| 74 68 6f 72 7b 0d 0a 48 | 75 67 68 65 73 2c 20 42 |thor{..H|ughes, B|
|00003810| 52 0d 0a 4d 75 72 70 68 | 79 2c 20 43 45 0d 0a 42 |R..Murph|y, CE..B|
|00003820| 61 72 6e 65 74 74 2c 20 | 4a 0d 0a 43 75 6e 6c 69 |arnett, |J..Cunli|
|00003830| 66 66 65 2c 20 57 4a 7d | 0d 0a 24 41 66 66 69 6c |ffe, WJ}|..$Affil|
|00003840| 69 61 74 69 6f 6e 7b 54 | 68 65 20 47 65 6e 20 49 |iation{T|he Gen I|
|00003850| 6e 66 69 72 6d 61 72 79 | 20 61 74 20 4c 65 65 64 |nfirmary| at Leed|
|00003860| 73 2c 20 4c 65 65 64 73 | 2c 20 45 6e 67 6c 61 6e |s, Leeds|, Englan|
|00003870| 64 7d 0d 0a 24 4a 6f 75 | 72 6e 61 6c 7b 42 72 20 |d}..$Jou|rnal{Br |
|00003880| 4a 20 44 65 72 6d 61 74 | 6f 6c 7d 0d 0a 24 56 6f |J Dermat|ol}..$Vo|
|00003890| 6c 75 6d 65 7b 31 32 31 | 7d 0d 0a 24 50 61 67 65 |lume{121|}..$Page|
|000038a0| 7b 36 32 33 2d 36 32 38 | 7d 0d 0a 24 44 61 74 65 |{623-628|}..$Date|
|000038b0| 7b 31 39 38 39 7d 0d 0a | 24 59 42 56 6f 6c 7b 31 |{1989}..|$YBVol{1|
|000038c0| 39 39 31 20 59 65 61 72 | 20 42 6f 6f 6b 20 6f 66 |991 Year| Book of|
|000038d0| 20 44 65 72 6d 61 74 6f | 6c 6f 67 79 7d 0d 0a 24 | Dermato|logy}..$|
|000038e0| 43 68 61 70 74 65 72 7b | 31 2d 36 7d 0d 0a 24 59 |Chapter{|1-6}..$Y|
|000038f0| 42 45 64 69 74 6f 72 7b | 44 72 73 2e 20 53 6f 62 |BEditor{|Drs. Sob|
|00003900| 65 72 20 61 6e 64 20 46 | 69 74 7a 70 61 74 72 69 |er and F|itzpatri|
|00003910| 63 6b 7d 0d 0a 24 54 61 | 62 6c 65 7b 7d 0d 0a 24 |ck}..$Ta|ble{}..$|
|00003920| 43 6f 6d 6d 65 6e 74 61 | 74 6f 72 7b 52 2e 53 2e |Commenta|tor{R.S.|
|00003930| 20 53 74 65 72 6e 2c 20 | 4d 2e 44 2e 7d 0d 0a 0d | Stern, |M.D.}...|
|00003940| 0a 43 6f 70 79 72 69 67 | 68 74 20 28 43 29 20 59 |.Copyrig|ht (C) Y|
|00003950| 65 61 72 20 42 6f 6f 6b | 20 4d 65 64 69 63 61 6c |ear Book| Medical|
|00003960| 20 50 75 62 6c 69 73 68 | 65 72 73 2c 20 49 6e 63 | Publish|ers, Inc|
|00003970| 2e 20 20 31 39 39 31 0d | 0a 0d 0a 31 39 39 31 20 |. 1991.|...1991 |
|00003980| 59 65 61 72 20 42 6f 6f | 6b 20 6f 66 20 44 65 72 |Year Boo|k of Der|
|00003990| 6d 61 74 6f 6c 6f 67 79 | 0d 0a 0d 0a 43 68 61 70 |matology|....Chap|
|000039a0| 74 65 72 20 31 2d 2d 41 | 63 6e 65 20 61 6e 64 20 |ter 1--A|cne and |
|000039b0| 52 65 6c 61 74 65 64 20 | 53 75 62 6a 65 63 74 73 |Related |Subjects|
|000039c0| 0d 0a 0d 0a 2d 2d 2d 2d | 2d 2d 2d 2d 2d 2d 2d 2d |....----|--------|
|000039d0| 2d 2d 2d 2d 2d 2d 2d 2d | 2d 2d 2d 2d 2d 2d 2d 2d |--------|--------|
|000039e0| 2d 2d 2d 2d 2d 2d 2d 2d | 2d 2d 2d 2d 2d 2d 2d 2d |--------|--------|
|000039f0| 2d 2d 2d 2d 2d 2d 2d 2d | 2d 2d 2d 2d 2d 2d 2d 2d |--------|--------|
|00003a00| 2d 2d 2d 2d 2d 2d 2d 2d | 2d 2d 2d 2d 2d 2d 2d 2d |--------|--------|
|00003a10| 2d 2d 0d 0a 53 74 72 61 | 74 65 67 79 20 6f 66 20 |--..Stra|tegy of |
|00003a20| 41 63 6e 65 20 54 68 65 | 72 61 70 79 20 57 69 74 |Acne The|rapy Wit|
|00003a30| 68 20 4c 6f 6e 67 2d 54 | 65 72 6d 20 41 6e 74 69 |h Long-T|erm Anti|
|00003a40| 62 69 6f 74 69 63 73 0d | 0a 0d 0a 48 75 67 68 65 |biotics.|...Hughe|
|00003a50| 73 20 42 52 3b 20 4d 75 | 72 70 68 79 20 43 45 3b |s BR; Mu|rphy CE;|
|00003a60| 20 42 61 72 6e 65 74 74 | 20 4a 3b 20 43 75 6e 6c | Barnett| J; Cunl|
|00003a70| 69 66 66 65 20 57 4a 0d | 0a 28 54 68 65 20 47 65 |iffe WJ.|.(The Ge|
|00003a80| 6e 20 49 6e 66 69 72 6d | 61 72 79 20 61 74 20 4c |n Infirm|ary at L|
|00003a90| 65 65 64 73 2c 20 4c 65 | 65 64 73 2c 20 45 6e 67 |eeds, Le|eds, Eng|
|00003aa0| 6c 61 6e 64 29 0d 0a 42 | 72 20 4a 20 44 65 72 6d |land)..B|r J Derm|
|00003ab0| 61 74 6f 6c 20 31 32 31 | 3a 36 32 33 2d 36 32 38 |atol 121|:623-628|
|00003ac0| 2c 20 31 39 38 39 0d 0a | 2d 2d 2d 2d 2d 2d 2d 2d |, 1989..|--------|
|00003ad0| 2d 2d 2d 2d 2d 2d 2d 2d | 2d 2d 2d 2d 2d 2d 2d 2d |--------|--------|
|00003ae0| 2d 2d 2d 2d 2d 2d 2d 2d | 2d 2d 2d 2d 2d 2d 2d 2d |--------|--------|
|00003af0| 2d 2d 2d 2d 2d 2d 2d 2d | 2d 2d 2d 2d 2d 2d 2d 2d |--------|--------|
|00003b00| 2d 2d 2d 2d 2d 2d 2d 2d | 2d 2d 2d 2d 2d 2d 2d 2d |--------|--------|
|00003b10| 2d 2d 2d 2d 2d 2d 0d 0a | 0d 0a 41 62 73 74 72 61 |------..|..Abstra|
|00003b20| 63 74 0d 0a 0d 0a 20 20 | 20 20 20 54 72 65 61 74 |ct.... | Treat|
|00003b30| 6d 65 6e 74 20 72 65 67 | 69 6d 65 6e 73 20 77 69 |ment reg|imens wi|
|00003b40| 74 68 20 61 6e 74 69 62 | 69 6f 74 69 63 73 20 66 |th antib|iotics f|
|00003b50| 6f 72 20 61 63 6e 65 20 | 72 65 6d 61 69 6e 73 20 |or acne |remains |
|00003b60| 65 6d 70 69 72 69 63 61 | 6c 2e 20 20 54 68 65 0d |empirica|l. The.|
|00003b70| 0a 6f 75 74 63 6f 6d 65 | 20 6f 66 20 63 6f 6e 76 |.outcome| of conv|
|00003b80| 65 6e 74 69 6f 6e 61 6c | 20 61 6e 74 69 62 69 6f |entional| antibio|
|00003b90| 74 69 63 20 74 72 65 61 | 74 6d 65 6e 74 20 77 61 |tic trea|tment wa|
|00003ba0| 73 20 69 6e 76 65 73 74 | 69 67 61 74 65 64 20 69 |s invest|igated i|
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|00003be0| 65 61 74 65 64 20 69 6e | 69 74 69 61 6c 6c 79 20 |eated in|itially |
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|00003c10| 20 74 6f 70 69 63 61 6c | 20 35 25 20 62 65 6e 7a | topical| 5% benz|
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|000046b0| 7d 0d 0a 24 44 61 74 65 | 7b 31 39 39 30 7d 0d 0a |}..$Date|{1990}..|
|000046c0| 24 59 42 56 6f 6c 7b 31 | 39 39 31 20 59 65 61 72 |$YBVol{1|991 Year|
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|000047c0| 53 75 62 6a 65 63 74 73 | 0d 0a 0d 0a 2d 2d 2d 2d |Subjects|....----|
|000047d0| 2d 2d 2d 2d 2d 2d 2d 2d | 2d 2d 2d 2d 2d 2d 2d 2d |--------|--------|
|000047e0| 2d 2d 2d 2d 2d 2d 2d 2d | 2d 2d 2d 2d 2d 2d 2d 2d |--------|--------|
|000047f0| 2d 2d 2d 2d 2d 2d 2d 2d | 2d 2d 2d 2d 2d 2d 2d 2d |--------|--------|
|00004800| 2d 2d 2d 2d 2d 2d 2d 2d | 2d 2d 2d 2d 2d 2d 2d 2d |--------|--------|
|00004810| 2d 2d 2d 2d 2d 2d 2d 2d | 2d 2d 0d 0a 53 75 70 65 |--------|--..Supe|
|00004820| 72 69 6f 72 20 41 6e 74 | 69 62 61 63 74 65 72 69 |rior Ant|ibacteri|
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|000048b0| 41 3b 20 43 6f 76 65 20 | 4a 48 3b 20 48 6f 6c 6c |A; Cove |JH; Holl|
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|00004910| 44 65 72 6d 61 74 6f 6c | 20 31 32 32 3a 32 33 33 |Dermatol| 122:233|
|00004920| 2d 32 34 34 2c 20 31 39 | 39 30 0d 0a 2d 2d 2d 2d |-244, 19|90..----|
|00004930| 2d 2d 2d 2d 2d 2d 2d 2d | 2d 2d 2d 2d 2d 2d 2d 2d |--------|--------|
|00004940| 2d 2d 2d 2d 2d 2d 2d 2d | 2d 2d 2d 2d 2d 2d 2d 2d |--------|--------|
|00004950| 2d 2d 2d 2d 2d 2d 2d 2d | 2d 2d 2d 2d 2d 2d 2d 2d |--------|--------|
|00004960| 2d 2d 2d 2d 2d 2d 2d 2d | 2d 2d 2d 2d 2d 2d 2d 2d |--------|--------|
|00004970| 2d 2d 2d 2d 2d 2d 2d 2d | 2d 2d 0d 0a 0d 0a 41 62 |--------|--....Ab|
|00004980| 73 74 72 61 63 74 0d 0a | 0d 0a 20 20 20 20 20 42 |stract..|.. B|
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|00005090| 20 72 65 73 69 73 74 61 | 6e 74 0d 0a 73 74 61 70 | resista|nt..stap|
|000050a0| 68 79 6c 6f 63 6f 63 63 | 69 20 6e 6f 74 65 64 20 |hylococc|i noted |
|000050b0| 69 6e 20 74 68 65 20 74 | 65 74 72 61 63 79 63 6c |in the t|etracycl|
|000050c0| 69 6e 65 20 63 6f 6d 70 | 61 72 65 64 20 77 69 74 |ine comp|ared wit|
|000050d0| 68 20 74 68 65 20 6d 69 | 6e 6f 63 79 63 6c 69 6e |h the mi|nocyclin|
|000050e0| 65 0d 0a 74 72 65 61 74 | 6d 65 6e 74 20 67 72 6f |e..treat|ment gro|
|000050f0| 75 70 20 73 68 6f 77 69 | 6e 67 20 61 6e 79 20 72 |up showi|ng any r|
|00005100| 65 6c 61 74 69 6f 6e 20 | 74 6f 20 63 6c 69 6e 69 |elation |to clini|
|00005110| 63 61 6c 20 64 69 73 65 | 61 73 65 2c 20 49 20 61 |cal dise|ase, I a|
|00005120| 6d 20 6e 6f 74 20 73 75 | 72 65 20 6f 66 20 74 68 |m not su|re of th|
|00005130| 65 0d 0a 63 6c 69 6e 69 | 63 61 6c 20 73 69 67 6e |e..clini|cal sign|
|00005140| 69 66 69 63 61 6e 63 65 | 20 6f 66 20 74 68 65 73 |ificance| of thes|
|00005150| 65 20 66 69 6e 64 69 6e | 67 73 2e 20 20 54 68 65 |e findin|gs. The|
|00005160| 73 65 20 6f 62 65 72 76 | 61 74 69 6f 6e 73 20 68 |se oberv|ations h|
|00005170| 61 72 64 6c 79 20 73 65 | 65 6d 0d 0a 73 75 72 70 |ardly se|em..surp|
|00005180| 72 69 73 69 6e 67 2c 20 | 67 69 76 65 6e 20 6d 69 |rising, |given mi|
|00005190| 6e 6f 63 79 63 6c 69 6e | 65 27 73 20 67 72 65 61 |nocyclin|e's grea|
|000051a0| 74 65 72 20 73 70 65 63 | 74 72 75 6d 20 6f 66 20 |ter spec|trum of |
|000051b0| 61 6e 74 69 73 74 61 70 | 68 79 6c 6f 63 6f 63 63 |antistap|hylococc|
|000051c0| 61 6c 0d 0a 61 63 74 69 | 76 69 74 79 2e 20 20 54 |al..acti|vity. T|
|000051d0| 68 65 20 6b 65 79 20 72 | 65 73 75 6c 74 73 20 6f |he key r|esults o|
|000051e0| 66 20 74 68 69 73 20 73 | 74 75 64 79 20 61 72 65 |f this s|tudy are|
|000051f0| 20 74 68 61 74 20 74 68 | 65 72 65 20 77 65 72 65 | that th|ere were|
|00005200| 20 6e 6f 20 73 75 62 73 | 74 61 6e 74 69 61 6c 0d | no subs|tantial.|
|00005210| 0a 64 69 66 66 65 72 65 | 6e 63 65 73 20 69 6e 20 |.differe|nces in |
|00005220| 63 6c 69 6e 69 63 61 6c | 20 69 6d 70 72 6f 76 65 |clinical| improve|
|00005230| 6d 65 6e 74 20 77 69 74 | 68 20 74 65 74 72 61 63 |ment wit|h tetrac|
|00005240| 79 63 6c 69 6e 65 20 61 | 6e 64 20 6d 69 6e 6f 63 |ycline a|nd minoc|
|00005250| 79 63 6c 69 6e 65 20 61 | 74 20 77 68 61 74 0d 0a |ycline a|t what..|
|00005260| 6d 6f 73 74 20 77 6f 75 | 6c 64 20 63 6f 6e 73 69 |most wou|ld consi|
|00005270| 64 65 72 20 74 6f 20 62 | 65 20 6d 6f 64 65 72 61 |der to b|e modera|
|00005280| 74 65 20 61 6e 64 20 65 | 71 75 69 76 61 6c 65 6e |te and e|quivalen|
|00005290| 74 20 64 6f 73 65 73 20 | 28 35 30 30 20 6d 67 20 |t doses |(500 mg |
|000052a0| 74 77 69 63 65 20 64 61 | 69 6c 79 0d 0a 76 73 2e |twice da|ily..vs.|
|000052b0| 20 35 30 20 6d 67 20 74 | 77 69 63 65 20 64 61 69 | 50 mg t|wice dai|
|000052c0| 6c 79 29 2e 20 20 54 68 | 65 20 62 61 63 74 65 72 |ly). Th|e bacter|
|000052d0| 69 6f 6c 6f 67 79 20 69 | 73 20 69 6e 74 65 72 65 |iology i|s intere|
|000052e0| 73 74 69 6e 67 2c 20 62 | 75 74 20 74 68 65 20 69 |sting, b|ut the i|
|000052f0| 6d 70 6f 72 74 61 6e 63 | 65 0d 0a 6f 66 20 64 65 |mportanc|e..of de|
|00005300| 6d 6f 6e 73 74 72 61 74 | 69 6e 67 20 67 72 65 61 |monstrat|ing grea|
|00005310| 74 65 72 20 61 6e 74 69 | 62 61 63 74 65 72 69 61 |ter anti|bacteria|
|00005320| 6c 20 61 63 74 69 76 69 | 74 79 20 61 6e 64 20 6c |l activi|ty and l|
|00005330| 65 73 73 20 73 74 61 70 | 68 79 6c 6f 63 6f 63 63 |ess stap|hylococc|
|00005340| 69 20 77 69 74 68 0d 0a | 61 6e 74 69 62 69 6f 74 |i with..|antibiot|
|00005350| 69 63 20 72 65 73 69 73 | 74 61 6e 63 65 20 69 6e |ic resis|tance in|
|00005360| 20 74 68 65 20 61 62 73 | 65 6e 63 65 20 6f 66 20 | the abs|ence of |
|00005370| 63 6c 69 6e 69 63 61 6c | 6c 79 20 72 65 6c 65 76 |clinical|ly relev|
|00005380| 61 6e 74 20 66 69 6e 64 | 69 6e 67 73 20 6d 75 73 |ant find|ings mus|
|00005390| 74 20 62 65 0d 0a 76 69 | 65 77 65 64 20 63 61 75 |t be..vi|ewed cau|
|000053a0| 74 69 6f 75 73 6c 79 2e | 2d 2d 52 2e 53 2e 20 53 |tiously.|--R.S. S|
|000053b0| 74 65 72 6e 2c 20 4d 2e | 44 2e 0d 0a 24 55 6e 69 |tern, M.|D...$Uni|
|000053c0| 71 75 65 5f 49 44 7b 59 | 52 45 30 30 30 30 38 7d |que_ID{Y|RE00008}|
|000053d0| 0d 0a 24 54 69 74 6c 65 | 7b 4c 6f 77 20 44 6f 73 |..$Title|{Low Dos|
|000053e0| 65 73 20 6f 66 20 5a 69 | 6e 63 20 47 6c 75 63 6f |es of Zi|nc Gluco|
|000053f0| 6e 61 74 65 20 66 6f 72 | 20 49 6e 66 6c 61 6d 6d |nate for| Inflamm|
|00005400| 61 74 6f 72 79 20 41 63 | 6e 65 7d 0d 0a 24 41 75 |atory Ac|ne}..$Au|
|00005410| 74 68 6f 72 7b 0d 0a 44 | 72 65 6e 6f 2c 20 42 0d |thor{..D|reno, B.|
|00005420| 0a 41 6d 62 6c 61 72 64 | 2c 20 50 0d 0a 41 67 61 |.Amblard|, P..Aga|
|00005430| 63 68 65 2c 20 50 0d 0a | 53 69 72 6f 74 2c 20 53 |che, P..|Sirot, S|
|00005440| 0d 0a 4c 69 74 6f 75 78 | 2c 20 50 7d 0d 0a 24 41 |..Litoux|, P}..$A|
|00005450| 66 66 69 6c 69 61 74 69 | 6f 6e 7b 48 6f 74 65 6c |ffiliati|on{Hotel|
|00005460| 20 44 69 65 75 2c 20 4e | 61 6e 74 65 73 3b 20 44 | Dieu, N|antes; D|
|00005470| 65 70 74 20 6f 66 20 44 | 65 72 6d 61 74 6f 6c 6f |ept of D|ermatolo|
|00005480| 67 79 2c 20 47 72 65 6e | 6f 62 6c 65 3b 20 44 65 |gy, Gren|oble; De|
|00005490| 70 74 20 6f 66 0d 0a 44 | 65 72 6d 61 74 6f 6c 6f |pt of..D|ermatolo|
|000054a0| 67 79 2c 20 42 65 73 61 | 6e 63 6f 6e 3b 20 4c 61 |gy, Besa|ncon; La|
|000054b0| 62 20 4c 61 62 63 61 74 | 61 6c 2c 20 4d 6f 6e 74 |b Labcat|al, Mont|
|000054c0| 72 6f 75 67 65 2c 20 46 | 72 61 6e 63 65 7d 0d 0a |rouge, F|rance}..|
|000054d0| 24 4a 6f 75 72 6e 61 6c | 7b 41 63 74 61 20 44 65 |$Journal|{Acta De|
|000054e0| 72 6d 20 56 65 6e 65 72 | 65 6f 6c 20 28 53 74 6f |rm Vener|eol (Sto|
|000054f0| 63 6b 68 29 7d 0d 0a 24 | 56 6f 6c 75 6d 65 7b 36 |ckh)}..$|Volume{6|
|00005500| 39 7d 0d 0a 24 50 61 67 | 65 7b 35 34 31 2d 35 34 |9}..$Pag|e{541-54|
|00005510| 33 7d 0d 0a 24 44 61 74 | 65 7b 31 39 38 39 7d 0d |3}..$Dat|e{1989}.|
|00005520| 0a 24 59 42 56 6f 6c 7b | 31 39 39 31 20 59 65 61 |.$YBVol{|1991 Yea|
|00005530| 72 20 42 6f 6f 6b 20 6f | 66 20 44 65 72 6d 61 74 |r Book o|f Dermat|
|00005540| 6f 6c 6f 67 79 7d 0d 0a | 24 43 68 61 70 74 65 72 |ology}..|$Chapter|
|00005550| 7b 31 2d 38 7d 0d 0a 24 | 59 42 45 64 69 74 6f 72 |{1-8}..$|YBEditor|
|00005560| 7b 44 72 73 2e 20 53 6f | 62 65 72 20 61 6e 64 20 |{Drs. So|ber and |
|00005570| 46 69 74 7a 70 61 74 72 | 69 63 6b 7d 0d 0a 24 54 |Fitzpatr|ick}..$T|
|00005580| 61 62 6c 65 7b 7d 0d 0a | 24 43 6f 6d 6d 65 6e 74 |able{}..|$Comment|
|00005590| 61 74 6f 72 7b 53 2e 41 | 2e 20 43 6f 6f 70 6d 61 |ator{S.A|. Coopma|
|000055a0| 6e 2c 20 4d 2e 44 2e 7d | 0d 0a 0d 0a 43 6f 70 79 |n, M.D.}|....Copy|
|000055b0| 72 69 67 68 74 20 28 43 | 29 20 59 65 61 72 20 42 |right (C|) Year B|
|000055c0| 6f 6f 6b 20 4d 65 64 69 | 63 61 6c 20 50 75 62 6c |ook Medi|cal Publ|
|000055d0| 69 73 68 65 72 73 2c 20 | 49 6e 63 2e 20 20 31 39 |ishers, |Inc. 19|
|000055e0| 39 31 0d 0a 0d 0a 31 39 | 39 31 20 59 65 61 72 20 |91....19|91 Year |
|000055f0| 42 6f 6f 6b 20 6f 66 20 | 44 65 72 6d 61 74 6f 6c |Book of |Dermatol|
|00005600| 6f 67 79 0d 0a 0d 0a 43 | 68 61 70 74 65 72 20 31 |ogy....C|hapter 1|
|00005610| 2d 2d 41 63 6e 65 20 61 | 6e 64 20 52 65 6c 61 74 |--Acne a|nd Relat|
|00005620| 65 64 20 53 75 62 6a 65 | 63 74 73 0d 0a 0d 0a 2d |ed Subje|cts....-|
|00005630| 2d 2d 2d 2d 2d 2d 2d 2d | 2d 2d 2d 2d 2d 2d 2d 2d |--------|--------|
|00005640| 2d 2d 2d 2d 2d 2d 2d 2d | 2d 2d 2d 2d 2d 2d 2d 2d |--------|--------|
|00005650| 2d 2d 2d 2d 2d 2d 2d 2d | 2d 2d 2d 2d 2d 2d 2d 2d |--------|--------|
|00005660| 2d 2d 2d 2d 2d 2d 2d 2d | 2d 2d 2d 2d 2d 2d 2d 2d |--------|--------|
|00005670| 2d 2d 2d 2d 2d 2d 2d 2d | 2d 2d 2d 2d 2d 0d 0a 4c |--------|-----..L|
|00005680| 6f 77 20 44 6f 73 65 73 | 20 6f 66 20 5a 69 6e 63 |ow Doses| of Zinc|
|00005690| 20 47 6c 75 63 6f 6e 61 | 74 65 20 66 6f 72 20 49 | Glucona|te for I|
|000056a0| 6e 66 6c 61 6d 6d 61 74 | 6f 72 79 20 41 63 6e 65 |nflammat|ory Acne|
|000056b0| 0d 0a 0d 0a 44 72 65 6e | 6f 20 42 3b 20 41 6d 62 |....Dren|o B; Amb|
|000056c0| 6c 61 72 64 20 50 3b 20 | 41 67 61 63 68 65 20 50 |lard P; |Agache P|
|000056d0| 3b 20 53 69 72 6f 74 20 | 53 3b 20 4c 69 74 6f 75 |; Sirot |S; Litou|
|000056e0| 78 20 50 0d 0a 28 48 6f | 74 65 6c 20 44 69 65 75 |x P..(Ho|tel Dieu|
|000056f0| 2c 20 4e 61 6e 74 65 73 | 3b 20 44 65 70 74 20 6f |, Nantes|; Dept o|
|00005700| 66 20 44 65 72 6d 61 74 | 6f 6c 6f 67 79 2c 20 47 |f Dermat|ology, G|
|00005710| 72 65 6e 6f 62 6c 65 3b | 20 44 65 70 74 20 6f 66 |renoble;| Dept of|
|00005720| 20 44 65 72 6d 61 74 6f | 6c 6f 67 79 2c 0d 0a 42 | Dermato|logy,..B|
|00005730| 65 73 61 6e 63 6f 6e 3b | 20 4c 61 62 20 4c 61 62 |esancon;| Lab Lab|
|00005740| 63 61 74 61 6c 2c 20 4d | 6f 6e 74 72 6f 75 67 65 |catal, M|ontrouge|
|00005750| 2c 20 46 72 61 6e 63 65 | 29 0d 0a 41 63 74 61 20 |, France|)..Acta |
|00005760| 44 65 72 6d 20 56 65 6e | 65 72 65 6f 6c 20 28 53 |Derm Ven|ereol (S|
|00005770| 74 6f 63 6b 68 29 20 36 | 39 3a 35 34 31 2d 35 34 |tockh) 6|9:541-54|
|00005780| 33 2c 20 31 39 38 39 0d | 0a 2d 2d 2d 2d 2d 2d 2d |3, 1989.|.-------|
|00005790| 2d 2d 2d 2d 2d 2d 2d 2d | 2d 2d 2d 2d 2d 2d 2d 2d |--------|--------|
|000057a0| 2d 2d 2d 2d 2d 2d 2d 2d | 2d 2d 2d 2d 2d 2d 2d 2d |--------|--------|
|000057b0| 2d 2d 2d 2d 2d 2d 2d 2d | 2d 2d 2d 2d 2d 2d 2d 2d |--------|--------|
|000057c0| 2d 2d 2d 2d 2d 2d 2d 2d | 2d 2d 2d 2d 2d 2d 2d 2d |--------|--------|
|000057d0| 2d 2d 2d 2d 2d 2d 2d 0d | 0a 0d 0a 41 62 73 74 72 |-------.|...Abstr|
|000057e0| 61 63 74 0d 0a 0d 0a 20 | 20 20 20 20 50 72 65 76 |act.... | Prev|
|000057f0| 69 6f 75 73 20 73 74 75 | 64 69 65 73 20 6f 66 20 |ious stu|dies of |
|00005800| 7a 69 6e 63 20 74 68 65 | 72 61 70 79 20 69 6e 20 |zinc the|rapy in |
|00005810| 61 63 6e 65 20 68 61 76 | 65 20 67 69 76 65 6e 20 |acne hav|e given |
|00005820| 69 6e 63 6f 6e 73 69 73 | 74 65 6e 74 20 72 65 73 |inconsis|tent res|
|00005830| 75 6c 74 73 2e 0d 0a 54 | 68 69 73 20 6d 75 6c 74 |ults...T|his mult|
|00005840| 69 63 65 6e 74 65 72 20 | 64 6f 75 62 6c 65 2d 62 |icenter |double-b|
|00005850| 6c 69 6e 64 20 74 72 69 | 61 6c 20 65 6e 72 6f 6c |lind tri|al enrol|
|00005860| 6c 65 64 20 36 36 20 70 | 61 74 69 65 6e 74 73 20 |led 66 p|atients |
|00005870| 77 68 6f 20 68 61 64 20 | 69 6e 66 6c 61 6d 6d 61 |who had |inflamma|
|00005880| 74 6f 72 79 0d 0a 61 63 | 6e 65 20 61 6e 64 20 61 |tory..ac|ne and a|
|00005890| 74 20 6c 65 61 73 74 20 | 31 35 20 70 75 73 74 75 |t least |15 pustu|
|000058a0| 6c 65 73 20 61 6e 64 2f | 6f 72 20 6e 6f 64 75 6c |les and/|or nodul|
|000058b0| 65 73 2e 20 20 4e 6f 6e | 65 20 68 61 64 20 6c 69 |es. Non|e had li|
|000058c0| 76 65 72 20 6f 72 20 6b | 69 64 6e 65 79 0d 0a 64 |ver or k|idney..d|
|000058d0| 69 73 65 61 73 65 2c 20 | 61 6e 64 20 6e 6f 6e 65 |isease, |and none|
|000058e0| 20 68 61 64 20 72 65 63 | 65 69 76 65 64 20 61 63 | had rec|eived ac|
|000058f0| 6e 65 20 74 72 65 61 74 | 6d 65 6e 74 20 66 6f 72 |ne treat|ment for|
|00005900| 20 61 74 20 6c 65 61 73 | 74 20 31 20 6d 6f 6e 74 | at leas|t 1 mont|
|00005910| 68 20 70 72 65 63 65 64 | 69 6e 67 0d 0a 74 68 65 |h preced|ing..the|
|00005920| 20 73 74 75 64 79 2e 20 | 20 50 61 74 69 65 6e 74 | study. | Patient|
|00005930| 73 20 72 65 63 65 69 76 | 65 64 20 65 69 74 68 65 |s receiv|ed eithe|
|00005940| 72 20 7a 69 6e 63 20 67 | 6c 75 63 6f 6e 61 74 65 |r zinc g|luconate|
|00005950| 2c 20 32 20 63 61 70 73 | 75 6c 65 73 20 70 65 72 |, 2 caps|ules per|
|00005960| 20 64 61 79 20 6f 66 20 | 31 30 30 0d 0a 6d 67 20 | day of |100..mg |
|00005970| 28 63 6f 72 72 65 73 70 | 6f 6e 64 69 6e 67 20 74 |(corresp|onding t|
|00005980| 6f 20 31 35 20 6d 67 20 | 5a 6e 28 2b 2b 29 29 2c |o 15 mg |Zn(++)),|
|00005990| 20 6f 72 20 70 6c 61 63 | 65 62 6f 20 63 61 70 73 | or plac|ebo caps|
|000059a0| 75 6c 65 73 2e 0d 0a 20 | 20 20 20 20 49 6e 66 6c |ules... | Infl|
|000059b0| 61 6d 6d 61 74 69 6f 6e | 20 73 63 6f 72 65 73 20 |ammation| scores |
|000059c0| 77 65 72 65 20 73 75 62 | 73 74 61 6e 74 69 61 6c |were sub|stantial|
|000059d0| 6c 79 20 6c 6f 77 65 72 | 20 69 6e 20 7a 69 6e 63 |ly lower| in zinc|
|000059e0| 2d 74 72 65 61 74 65 64 | 20 70 61 74 69 65 6e 74 |-treated| patient|
|000059f0| 73 0d 0a 61 66 74 65 72 | 20 31 20 6d 6f 6e 74 68 |s..after| 1 month|
|00005a00| 2e 20 20 54 77 65 6c 76 | 65 20 6f 66 20 74 68 65 |. Twelv|e of the|
|00005a10| 20 33 32 20 7a 69 6e 63 | 2d 74 72 65 61 74 65 64 | 32 zinc|-treated|
|00005a20| 20 70 61 74 69 65 6e 74 | 73 20 61 6e 64 20 33 20 | patient|s and 3 |
|00005a30| 6f 66 20 74 68 65 20 33 | 34 20 70 6c 61 63 65 62 |of the 3|4 placeb|
|00005a40| 6f 0d 0a 72 65 63 69 70 | 69 65 6e 74 73 20 77 65 |o..recip|ients we|
|00005a50| 72 65 20 6d 61 72 6b 65 | 64 6c 79 20 69 6d 70 72 |re marke|dly impr|
|00005a60| 6f 76 65 64 20 61 66 74 | 65 72 20 32 20 6d 6f 6e |oved aft|er 2 mon|
|00005a70| 74 68 73 3b 20 63 6f 6d | 70 61 72 61 62 6c 65 20 |ths; com|parable |
|00005a80| 72 65 73 75 6c 74 73 20 | 77 65 72 65 20 73 65 65 |results |were see|
|00005a90| 6e 0d 0a 77 68 65 6e 20 | 70 61 74 69 65 6e 74 73 |n..when |patients|
|00005aa0| 20 6f 66 66 65 72 65 64 | 20 74 68 65 69 72 20 6f | offered| their o|
|00005ab0| 70 69 6e 69 6f 6e 73 20 | 6f 66 20 74 68 65 20 63 |pinions |of the c|
|00005ac0| 6c 69 6e 69 63 61 6c 20 | 63 6f 75 72 73 65 2e 20 |linical |course. |
|00005ad0| 20 53 65 76 65 72 61 6c | 0d 0a 7a 69 6e 63 2d 74 | Several|..zinc-t|
|00005ae0| 72 65 61 74 65 64 20 70 | 61 74 69 65 6e 74 73 20 |reated p|atients |
|00005af0| 68 61 64 20 73 6c 69 67 | 68 74 20 67 61 73 74 72 |had slig|ht gastr|
|00005b00| 61 6c 67 69 61 20 61 6e | 64 20 32 20 72 65 70 6f |algia an|d 2 repo|
|00005b10| 72 74 65 64 20 61 62 64 | 6f 6d 69 6e 61 6c 20 70 |rted abd|ominal p|
|00005b20| 61 69 6e 2e 0d 0a 54 68 | 65 20 6d 65 61 6e 20 70 |ain...Th|e mean p|
|00005b30| 6c 61 73 6d 61 20 7a 69 | 6e 63 20 6c 65 76 65 6c |lasma zi|nc level|
|00005b40| 20 61 66 74 65 72 20 32 | 20 6d 6f 6e 74 68 73 20 | after 2| months |
|00005b50| 6f 66 20 74 72 65 61 74 | 6d 65 6e 74 20 68 61 64 |of treat|ment had|
|00005b60| 20 69 6e 63 72 65 61 73 | 65 64 20 66 72 6f 6d 20 | increas|ed from |
|00005b70| 39 35 32 0d 0a 74 6f 20 | 31 2c 31 30 33 20 6d 75 |952..to |1,103 mu|
|00005b80| 5f 67 2f 4c 2e 20 20 41 | 20 6c 6f 77 20 64 6f 73 |_g/L. A| low dos|
|00005b90| 65 20 6f 66 20 7a 69 6e | 63 20 67 6c 75 63 6f 6e |e of zin|c glucon|
|00005ba0| 61 74 65 20 68 61 73 20 | 62 65 6e 65 66 69 63 69 |ate has |benefici|
|00005bb0| 61 6c 20 65 66 66 65 63 | 74 73 20 69 6e 0d 0a 70 |al effec|ts in..p|
|00005bc0| 61 74 69 65 6e 74 73 20 | 77 69 74 68 20 69 6e 66 |atients |with inf|
|00005bd0| 6c 61 6d 6d 61 74 6f 72 | 79 20 61 63 6e 65 2e 0d |lammator|y acne..|
|00005be0| 0a 0d 0a 50 6f 73 74 2d | 43 6f 6d 6d 65 6e 74 0d |...Post-|Comment.|
|00005bf0| 0a 0d 0a 20 20 20 20 20 | 54 68 69 73 20 61 72 74 |... |This art|
|00005c00| 69 63 6c 65 2c 20 61 6e | 6f 74 68 65 72 20 69 6e |icle, an|other in|
|00005c10| 20 61 20 73 65 72 69 65 | 73 20 6f 66 20 70 75 62 | a serie|s of pub|
|00005c20| 6c 69 63 61 74 69 6f 6e | 73 20 74 68 61 74 20 73 |lication|s that s|
|00005c30| 74 61 72 74 65 64 20 6d | 6f 72 65 20 74 68 61 6e |tarted m|ore than|
|00005c40| 0d 0a 31 30 20 79 65 61 | 72 73 20 61 67 6f 20 28 |..10 yea|rs ago (|
|00005c50| 31 29 2c 20 64 65 73 63 | 72 69 62 65 73 20 74 68 |1), desc|ribes th|
|00005c60| 65 20 70 6f 74 65 6e 74 | 69 61 6c 20 62 65 6e 65 |e potent|ial bene|
|00005c70| 66 69 63 69 61 6c 20 65 | 66 66 65 63 74 20 6f 66 |ficial e|ffect of|
|00005c80| 20 6f 72 61 6c 20 7a 69 | 6e 63 20 69 6e 0d 0a 74 | oral zi|nc in..t|
|00005c90| 68 65 20 74 72 65 61 74 | 6d 65 6e 74 20 6f 66 20 |he treat|ment of |
|00005ca0| 61 63 6e 65 2e 20 20 42 | 65 63 61 75 73 65 20 6f |acne. B|ecause o|
|00005cb0| 66 20 74 68 65 20 6c 61 | 63 6b 20 6f 66 20 63 6f |f the la|ck of co|
|00005cc0| 6e 73 69 73 74 65 6e 63 | 79 20 6f 66 20 74 68 65 |nsistenc|y of the|
|00005cd0| 20 72 65 73 75 6c 74 73 | 20 61 6e 64 0d 0a 62 65 | results| and..be|
|00005ce0| 63 61 75 73 65 20 6f 66 | 20 74 68 65 20 68 69 67 |cause of| the hig|
|00005cf0| 68 20 69 6e 63 69 64 65 | 6e 63 65 20 6f 66 20 67 |h incide|nce of g|
|00005d00| 61 73 74 72 6f 69 6e 74 | 65 73 74 69 6e 61 6c 20 |astroint|estinal |
|00005d10| 73 69 64 65 20 65 66 66 | 65 63 74 73 20 6f 66 20 |side eff|ects of |
|00005d20| 6f 72 61 6c 20 7a 69 6e | 63 2c 0d 0a 65 6e 74 68 |oral zin|c,..enth|
|00005d30| 75 73 69 61 73 6d 20 66 | 6f 72 20 74 68 69 73 20 |usiasm f|or this |
|00005d40| 74 68 65 72 61 70 79 20 | 68 61 73 20 77 61 6e 65 |therapy |has wane|
|00005d50| 64 20 63 6f 6e 73 69 64 | 65 72 61 62 6c 79 20 69 |d consid|erably i|
|00005d60| 6e 20 72 65 63 65 6e 74 | 20 79 65 61 72 73 2e 20 |n recent| years. |
|00005d70| 20 49 20 64 6f 20 6e 6f | 74 0d 0a 74 68 69 6e 6b | I do no|t..think|
|00005d80| 20 74 68 61 74 20 6d 61 | 6e 79 20 70 72 61 63 74 | that ma|ny pract|
|00005d90| 69 74 69 6f 6e 65 72 73 | 20 77 69 6c 6c 20 62 65 |itioners| will be|
|00005da0| 20 74 65 6d 70 74 65 64 | 20 74 6f 20 61 62 61 6e | tempted| to aban|
|00005db0| 64 6f 6e 20 74 68 65 69 | 72 20 65 73 74 61 62 6c |don thei|r establ|
|00005dc0| 69 73 68 65 64 0d 0a 61 | 63 6e 65 20 74 72 65 61 |ished..a|cne trea|
|00005dd0| 74 6d 65 6e 74 20 72 65 | 67 69 6d 65 6e 73 20 69 |tment re|gimens i|
|00005de0| 6e 20 66 61 76 6f 72 20 | 6f 66 20 7a 69 6e 63 20 |n favor |of zinc |
|00005df0| 67 6c 75 63 6f 6e 61 74 | 65 20 6f 6e 20 74 68 65 |gluconat|e on the|
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|000063f0| 65 2c 20 31 32 2d 34 31 | 20 6d 6f 6e 74 68 73 29 |e, 12-41| months)|
+--------+-------------------------+-------------------------+--------+--------+
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